Contour matching using ant colony optimization and curve evolution

Shape retrieval is a very important topic in computer vision. Image retrieval consists of selecting images that fulfil specific criteria from a collection of images. This thesis concentrates on contour-based image retrieval, in which we only explore the information located on the shape contour. There are many different kinds of shape retrieval methods. Most of the research in this field has till now concentrated on matching methods and how to achieve a meaningful correspondence. The matching process consist of finding correspondence between the points located on the designed contours. However, the huge number of incorporated points in the correspondence makes the matching process more complex. Furthermore, this scheme does not support computation of the correspondence intuitively without considering noise effect and distortions. Hence, heuristics methods are convoked to find acceptable solution. Moreover, some researches focus on improving polygonal modelling methods of a contour in such a way that the resulted contour is a good approximation of the original contour, which can be used to reduce the number of incorporated points in the matching. In this thesis, a novel approach for Ant Colony Optimization (ACO) contour matching that can be used to find an acceptable matching between contour shapes is developed. A polygonal evolution method proposed previously is selected to simplify the extracted contour. The main reason behind selecting this method is due to the use of a stopping criterion which must be predetermined. The match process is formulated as a Quadratic Assignment Problem (QAP) and resolved by using ACO. An approximated similarity is computed using original shape context descriptor and the Euclidean metric. The experimental results justify that the proposed approach is invariant to noise and distortions, and it is more robust to noise and distortion compared to the previously introduced Dominant Point (DP) Approach

Contour matching using ant colony optimization and curve evolution

Shape retrieval is a very important topic in computer vision. Image retrieval consists of selecting images that fulfil specific criteria from a collection of images. This thesis concentrates on contour-based image retrieval, in which we only explore the information located on the shape contour. There are many different kinds of shape retrieval methods. Most of the research in this field has till now concentrated on matching methods and how to achieve a meaningful correspondence. The matching process consist of finding correspondence between the points located on the designed contours. However, the huge number of incorporated points in the correspondence makes the matching process more complex. Furthermore, this scheme does not support computation of the correspondence intuitively without considering noise effect and distortions. Hence, heuristics methods are convoked to find acceptable solution. Moreover, some researches focus on improving polygonal modelling methods of a contour in such a way that the resulted contour is a good approximation of the original contour, which can be used to reduce the number of incorporated points in the matching. In this thesis, a novel approach for Ant Colony Optimization (ACO) contour matching that can be used to find an acceptable matching between contour shapes is developed. A polygonal evolution method proposed previously is selected to simplify the extracted contour. The main reason behind selecting this method is due to the use of a stopping criterion which must be predetermined. The match process is formulated as a Quadratic Assignment Problem (QAP) and resolved by using ACO. An approximated similarity is computed using original shape context descriptor and the Euclidean metric. The experimental results justify that the proposed approach is invariant to noise and distortions, and it is more robust to noise and distortion compared to the previously introduced Dominant Point (DP) Approach. This work serves as the fundamental study for assessing the Bender Test to diagnose dyslexic and non-dyslexic symptom in children

Ringed Seal Search for Global Optimization via a Sensitive Search Model.

The efficiency of a metaheuristic algorithm for global optimization is based on its ability to search and find the global optimum. However, a good search often requires to be balanced between exploration and exploitation of the search space. In this paper, a new metaheuristic algorithm called Ringed Seal Search (RSS) is introduced. It is inspired by the natural behav-ior of the seal pup. This algorithm mimics the seal pup movement behavior and its ability to search and choose the best lair to escape predators. The scenario starts once the seal mother gives birth to a new pup in a birthing lair that is constructed for this purpose. The seal pup strategy consists of searching and selecting the best lair by performing a random walk to find a new lair. Affected by the sensitive nature of seals against external noise emit-ted by predators, the random walk of the seal pup takes two different search states, normal state and urgent state. In the normal state, the pup performs an intensive search between closely adjacent lairs; this movement is modeled via a Brownian walk. In an urgent state, the pup leaves the proximity area and performs an extensive search to find a new lair from sparse targets; this movement is modeled via a Levy walk. The switch between these two states is realized by the random noise emitted by predators. The algorithm keeps switching between normal and urgent states until the global optimum is reached. Tests and valida-tions were performed using fifteen benchmark test functions to compare the performance of RSS with other baseline algorithms. The results show that RSS is more efficient than Genetic Algorithm, Particles Swarm Optimization and Cuckoo Search in terms of conver-gence rate to the global optimum. The RSS shows an improvement in terms of balance between exploration (extensive) and exploitation (intensive) of the search space. The RSS can efficiently mimic seal pups behavior to find best lair and provide a new algorithm to be used in global optimization problems

Bio-inspired computation: Recent development on the modifications of the cuckoo search algorithm

Presently, the Cuckoo Search algorithm is attracting unprecedented attention from the research community and applications of the algorithm are expected to increase in number rapidly in the future. The purpose of this study is to assist potential developers in selecting the most suitable cuckoo search variant, provide proper guidance in future modifications and ease the selection of the optimal cuckoo search parameters. Several researchers have attempted to apply several modifications to the original cuckoo search algorithm in order to advance its effectiveness. This paper reviews the recent advances of these modifications made to the original cuckoo search by analyzing recent published papers tackling this subject. Additionally, the influences of various parameter settings regarding cuckoo search are taken into account in order to provide their optimal settings for specific problem classes. In order to estimate the qualities of the modifications, the percentage improvements made by the modified cuckoo search over the original cuckoo search for some selected reviews studies are computed. It is found that the population reduction and usage of biased random walk are the most frequently used modifications. This study can be used by both expert and novice researchers for outlining directions for future development, and to find the best modifications, together with the corresponding optimal setting of parameters for specific problems. The review can also serve as a benchmark for further modifications of the original cuckoo search

Validation of a Novel Fluorescent Lateral Flow Assay for Rapid Qualitative and Quantitative Assessment of Total Anti-SARS-CoV-2 S-RBD Binding Antibody Units (BAU) from Plasma or Fingerstick Whole-Blood of COVID-19 Vaccinees

Background: Limited commercial LFA assays are available to provide a reliable quantitative measurement of the total binding antibody units (BAU/mL) against the receptor-binding domain of the SARS-CoV-2 spike protein (S-RBD). Aim: This study aimed to evaluate the performance of the fluorescence LFA FinecareTM 2019-nCoV S-RBD test along with its reader (Model No.: FS-113) against the following reference methods: (i) the FDA-approved GenScript surrogate virus-neutralizing assay (sVNT); and (ii) three highly performing automated immunoassays: BioMérieux VIDAS®3, Ortho VITROS®, and Mindray CL-900i®. Methods: Plasma from 488 vaccinees was tested by all aforementioned assays. Fingerstick whole-blood samples from 156 vaccinees were also tested by FinecareTM. Results and conclusions: FinecareTM showed 100% specificity, as none of the pre-pandemic samples tested positive. Equivalent FinecareTM results were observed among the samples taken from fingerstick or plasma (Pearson correlation r = 0.9, p < 0.0001), suggesting that fingerstick samples are sufficient to quantitate the S-RBD BAU/mL. A moderate correlation was observed between FinecareTM and sVNT (r = 0.5, p < 0.0001), indicating that FinecareTM can be used for rapid prediction of the neutralizing antibody (nAb) post-vaccination. FinecareTM BAU results showed strong correlation with VIDAS®3 (r = 0.6, p < 0.0001) and moderate correlation with VITROS® (r = 0.5, p < 0.0001) and CL-900i® (r = 0.4, p < 0.0001), suggesting that FinecareTM can be used as a surrogate for the advanced automated assays to measure S-RBD BAU/mL.This work was made possible by grant number UREP28-173-3-057 from the Qatar National Research Fund (a member of Qatar Foundation). The statements made herein are solely the responsibility of the authors

EPIdemiology of Surgery-Associated Acute Kidney Injury (EPIS-AKI) : Study protocol for a multicentre, observational trial

More than 300 million surgical procedures are performed each year. Acute kidney injury (AKI) is a common complication after major surgery and is associated with adverse short-term and long-term outcomes. However, there is a large variation in the incidence of reported AKI rates. The establishment of an accurate epidemiology of surgery-associated AKI is important for healthcare policy, quality initiatives, clinical trials, as well as for improving guidelines. The objective of the Epidemiology of Surgery-associated Acute Kidney Injury (EPIS-AKI) trial is to prospectively evaluate the epidemiology of AKI after major surgery using the latest Kidney Disease: Improving Global Outcomes (KDIGO) consensus definition of AKI. EPIS-AKI is an international prospective, observational, multicentre cohort study including 10 000 patients undergoing major surgery who are subsequently admitted to the ICU or a similar high dependency unit. The primary endpoint is the incidence of AKI within 72 hours after surgery according to the KDIGO criteria. Secondary endpoints include use of renal replacement therapy (RRT), mortality during ICU and hospital stay, length of ICU and hospital stay and major adverse kidney events (combined endpoint consisting of persistent renal dysfunction, RRT and mortality) at day 90. Further, we will evaluate preoperative and intraoperative risk factors affecting the incidence of postoperative AKI. In an add-on analysis, we will assess urinary biomarkers for early detection of AKI. EPIS-AKI has been approved by the leading Ethics Committee of the Medical Council North Rhine-Westphalia, of the Westphalian Wilhelms-University Münster and the corresponding Ethics Committee at each participating site. Results will be disseminated widely and published in peer-reviewed journals, presented at conferences and used to design further AKI-related trials. Trial registration number NCT04165369

Tocilizumab in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial

Background: In this study, we aimed to evaluate the effects of tocilizumab in adult patients admitted to hospital with COVID-19 with both hypoxia and systemic inflammation. Methods: This randomised, controlled, open-label, platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]), is assessing several possible treatments in patients hospitalised with COVID-19 in the UK. Those trial participants with hypoxia (oxygen saturation &lt;92% on air or requiring oxygen therapy) and evidence of systemic inflammation (C-reactive protein ≥75 mg/L) were eligible for random assignment in a 1:1 ratio to usual standard of care alone versus usual standard of care plus tocilizumab at a dose of 400 mg–800 mg (depending on weight) given intravenously. A second dose could be given 12–24 h later if the patient's condition had not improved. The primary outcome was 28-day mortality, assessed in the intention-to-treat population. The trial is registered with ISRCTN (50189673) and ClinicalTrials.gov (NCT04381936). Findings: Between April 23, 2020, and Jan 24, 2021, 4116 adults of 21 550 patients enrolled into the RECOVERY trial were included in the assessment of tocilizumab, including 3385 (82%) patients receiving systemic corticosteroids. Overall, 621 (31%) of the 2022 patients allocated tocilizumab and 729 (35%) of the 2094 patients allocated to usual care died within 28 days (rate ratio 0·85; 95% CI 0·76–0·94; p=0·0028). Consistent results were seen in all prespecified subgroups of patients, including those receiving systemic corticosteroids. Patients allocated to tocilizumab were more likely to be discharged from hospital within 28 days (57% vs 50%; rate ratio 1·22; 1·12–1·33; p&lt;0·0001). Among those not receiving invasive mechanical ventilation at baseline, patients allocated tocilizumab were less likely to reach the composite endpoint of invasive mechanical ventilation or death (35% vs 42%; risk ratio 0·84; 95% CI 0·77–0·92; p&lt;0·0001). Interpretation: In hospitalised COVID-19 patients with hypoxia and systemic inflammation, tocilizumab improved survival and other clinical outcomes. These benefits were seen regardless of the amount of respiratory support and were additional to the benefits of systemic corticosteroids. Funding: UK Research and Innovation (Medical Research Council) and National Institute of Health Research

Convalescent plasma in patients admitted to hospital with COVID-19 (RECOVERY): a randomised controlled, open-label, platform trial

Background: Many patients with COVID-19 have been treated with plasma containing anti-SARS-CoV-2 antibodies. We aimed to evaluate the safety and efficacy of convalescent plasma therapy in patients admitted to hospital with COVID-19. Methods: This randomised, controlled, open-label, platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]) is assessing several possible treatments in patients hospitalised with COVID-19 in the UK. The trial is underway at 177 NHS hospitals from across the UK. Eligible and consenting patients were randomly assigned (1:1) to receive either usual care alone (usual care group) or usual care plus high-titre convalescent plasma (convalescent plasma group). The primary outcome was 28-day mortality, analysed on an intention-to-treat basis. The trial is registered with ISRCTN, 50189673, and ClinicalTrials.gov, NCT04381936. Findings: Between May 28, 2020, and Jan 15, 2021, 11558 (71%) of 16287 patients enrolled in RECOVERY were eligible to receive convalescent plasma and were assigned to either the convalescent plasma group or the usual care group. There was no significant difference in 28-day mortality between the two groups: 1399 (24%) of 5795 patients in the convalescent plasma group and 1408 (24%) of 5763 patients in the usual care group died within 28 days (rate ratio 1·00, 95% CI 0·93–1·07; p=0·95). The 28-day mortality rate ratio was similar in all prespecified subgroups of patients, including in those patients without detectable SARS-CoV-2 antibodies at randomisation. Allocation to convalescent plasma had no significant effect on the proportion of patients discharged from hospital within 28 days (3832 [66%] patients in the convalescent plasma group vs 3822 [66%] patients in the usual care group; rate ratio 0·99, 95% CI 0·94–1·03; p=0·57). Among those not on invasive mechanical ventilation at randomisation, there was no significant difference in the proportion of patients meeting the composite endpoint of progression to invasive mechanical ventilation or death (1568 [29%] of 5493 patients in the convalescent plasma group vs 1568 [29%] of 5448 patients in the usual care group; rate ratio 0·99, 95% CI 0·93–1·05; p=0·79). Interpretation: In patients hospitalised with COVID-19, high-titre convalescent plasma did not improve survival or other prespecified clinical outcomes. Funding: UK Research and Innovation (Medical Research Council) and National Institute of Health Research

Dimethyl fumarate in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial

Dimethyl fumarate (DMF) inhibits inflammasome-mediated inflammation and has been proposed as a treatment for patients hospitalised with COVID-19. This randomised, controlled, open-label platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]), is assessing multiple treatments in patients hospitalised for COVID-19 (NCT04381936, ISRCTN50189673). In this assessment of DMF performed at 27 UK hospitals, adults were randomly allocated (1:1) to either usual standard of care alone or usual standard of care plus DMF. The primary outcome was clinical status on day 5 measured on a seven-point ordinal scale. Secondary outcomes were time to sustained improvement in clinical status, time to discharge, day 5 peripheral blood oxygenation, day 5 C-reactive protein, and improvement in day 10 clinical status. Between 2 March 2021 and 18 November 2021, 713 patients were enroled in the DMF evaluation, of whom 356 were randomly allocated to receive usual care plus DMF, and 357 to usual care alone. 95% of patients received corticosteroids as part of routine care. There was no evidence of a beneficial effect of DMF on clinical status at day 5 (common odds ratio of unfavourable outcome 1.12; 95% CI 0.86-1.47; p = 0.40). There was no significant effect of DMF on any secondary outcome

Ringed seal search for global optimization via a sensitive search model / Younes Saadi

This thesis proposes a nature-inspired metaheuristic algorithm for global optimization. The proposed algorithm, which is called Ringed Seal Search (RSS), is inspired from the movement of the animal ringed seal. The proposed algorithm is characterized by a search model namely the sensitive search model, where the exploitation-exploration is adaptively balanced. The quality of the algorithm is comprehensively evaluated on various standard benchmark test functions using variety of quality metrics and using three baseline algorithms for comparison. The time consumption analysis shows that RSS consumes less time compared to its homologs. This result is compatible with the convergence analysis. The solution quality analysis demonstrates that the convergence speed of RSS obtained better solution quality, which can be interpreted as a mature search. The diversity evaluation shows that the proposed algorithm achieved an optimal diversity values in most of the benchmark test functions. The experimental results show that the proposed algorithm in this thesis improves the global optimization quality in uni-objective and multi-objective environments while the exploitation and exploration are adaptively balanced. Finally, the proposed algorithm is applied on a data clustering case study using seven benchmark datasets to validate and check its ability to solve real optimization problems. The obtained results show that the proposed algorithm can be used for data clustering